How Tesamorelin Works — and What Animal Studies Tell Us
Tesamorelin (a GHRH analog) activates pituitary GHRH receptors, boosting pulsatile GH and hepatic IGF-1 to drive lipolysis and anti-lipogenic effects. Foundational animal studies in rats and dogs—supported by FDA reviews—show dose-responsive GH/IGF-1 rises and class-consistent, reversible findings at higher exposures, with negative genotoxicity and no impairment of rat fertility at clinically comparable exposure.